Match a Weight Loss Diet to YOUR DNA (psst… doesn’t work)

“There was no significant difference in weight change among participants matched vs mismatched to their diet assignment,” the researchers wrote. There was also no DNA/diet interaction for waist circumference, body mass index, or body fat percentage.

“I had this whole rationale for why these three [DNA variants] would have an effect,” said Stanford’s Christopher Gardner, co-author of the $8 million study. He previously led a smaller study, in 2010, finding that overweight women whose genotype matched their diet lost 13 pounds in a year while those who were mismatched lost just over 4 pounds. “But let’s cut to the chase: We didn’t replicate that study, we didn’t even come close. This didn’t work.”

The source article can be found here.

Beware of companies selling you stuff based on junk science. 


How to Eat to Lose Weight

It’s important to provide information on the healthfulness of food choices, rather than to simply recommend decreasing portion sizes.

There is a link to the study abstract in the source article here.

Small number of subjects but a crossover design RCT.

English Translation:

Portion sizes and food choices matter.

(so if you go out for Tex Mex eat half the number of tortillas you usually eat and take home half of what’s on your plate for another meal).